"Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias."
Ioannidis JPA (2005) Why most published research findings are false. PLoS Med 2: e124. doi: http://dx.doi.org/10.1371/journal.pmed.0020124
Also In cancer science, many 'discoveries' don't hold up.
Reproduced from <! a href="http://www.fasttestweb.com/test-development-cycle.php" target="x">www.fasttestweb.com/test-development-cycle.php with permission of Nathan A. Thompson, Ph.D., Vice President, Assessment Systems Corporation.
Notes and Quotes ... Rasch Measurement Transactions, 2011, 25:3, 1338
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